What is the OXIRIS Filter Set?
OXIRIS is the only filter set available in the US that performs multiple blood purification therapies simultaneously, including continuous renal replacement therapy (CRRT) and the removal of cytokines and inflammatory mediators from the blood.
How does the OXIRIS filter work?
The OXIRIS filter set has a three-layer membrane structure:1-3
The enhanced AN69 membrane enables adsorption of cytokines and toxins while providing renal support by diffusion and convection.
The PEI (polyethyleneimine) surface treatment allows for the adsorption of endotoxins, and provides renal support through removal of fluids and toxins by diffusion and convection.
The heparin graft on the membrane reduces membrane thrombogenicity.
“We are learning more about how the real threat in COVID-19-induced sepsis is the inflammatory response and the storm of cytokines released during COVID-19 infection. Additionally, dialysis filter clotting has been a tremendous challenge in providing dialysis therapy for our COVID-19 patients. We have been losing filters to clotting at a very fast rate. For patients with imminent respiratory failure who need blood purification, we believe the OXIRIS filter could help us manage their treatment. The OXIRIS blood purification system may help to reduce the cytokines that we believe are associated with the COVID-19 infection.”
-Dr. Chris Kwoh, Nephrologist at Houston Healthcare Northwest, 1st HCA in the U.S. to use the OXIRIS Filter Set