Liver Detoxification

MARS + PRISMAFLEX: Joining forces for the treatment of drug overdose

Dual Powered. Single Purpose.

The MARS (Molecular Adsorbent Recirculating System) therapy works easily with your PRISMAFLEX System to support the removal of harmful drugs and poisons in combination with CRRT. Tap the blue buttons in the top left of the image below for more info.
Photo with labels for MARS Monitor, X-MARS Kit, connected to the PRISMAFLEX System.
MARS is comprised of a blood circuit, an albumin circuit, and a classic CRRT circuit.

X-Mars Kit includes the 1) MARS FLUX 2.1 - high flux dialyzer especially suited for removing protein-bound toxins from the patient's blood by means of an HSA dialysate, 2) diaMARS IE250 - this adsorber cartridge is filled with an ion-exchanger resin, especially suited for eliminating anionic molecules, 3) diaMARS AC250 and 4) diaFLUX 1.4

MARS Monitor for PRISMAFLEX with labels for bag holder, albumin dialysate heater, blood leak detector, particle filter holder, holder for diaLFUX filter holder (when not used in conbination with PRISMAFLEX System, air trap holder with level detector, albumin pump.

How MARS Works

When a patient comes in from a drug overdose or from a poison that’s killing the liver cells, albumin dialysis using the MARS therapy helps me to stabilize my patient, and gives them the chance to recover. If you have a dialysis service, you can have MARS up and running very easily.

Tarek Hassanein, MD

Established first MARS program in the US, Over 500 patients treated with MARS

The PRISMAFLEX and PRISMAX Systems are intended for:
Continuous Renal Replacement Therapy (CRRT) for patients weighing 20 kilograms or more with acute renal failure and/or fluid overload.

Therapeutic Plasma Exchange (TPE) therapy for patients weighing 20 kilograms or more with diseases where fluid removal of plasma components is indicated.

Rx Only. For safe and proper use of products mentioned herein refer to the appropriate Instructions for Use or Operator's Manual.

PHOXILLUM and PRISMASOL Renal Replacement Solution Indications and Important Risk Information

Indications and Usage 
PRISMASOL and PHOXILLUM solutions are indicated in pediatric and adult patients for use as a replacement solution in Continuous Renal Replacement Therapy (CRRT) to replace plasma volume removed by ultrafiltration and to correct electrolyte and acid-base imbalances. They may also be used in case of drug poisoning when CRRT is used to remove dialyzable substances.

Warnings and Precautions 
Electrolyte and Volume Abnormalities
PHOXILLUM and PRISMASOL solutions can affect electrolytes and volume and may result in hyperkalemia or hyperphosphatemia. Monitor hemodynamic status and fluid inputs and outputs, potassium, phosphorous, calcium, other electrolytes and acid-base balance throughout the procedure. Abnormalities may be corrected by changing the formulation of replacement solution and/or dialysate, supplementation, or adjusting flow rates appropriately. PHOXILLUM replacement solutions contain hydrogen phosphate, a weak acid that may increase the risk of metabolic acidosis.

Blood Glucose Abnormalities
The use of PRISMASOL and PHOXILLUM replacement solutions can affect blood glucose levels resulting in hypo- or hyper-glycemia depending upon the dextrose content of the replacement solution. Monitor blood glucose levels regularly. Patients may require initiation of or modification of antidiabetic therapy or other corrective measures during treatment.

Please see PHOXILLUM and PRISMASOL Solutions full Prescribing Information.

MARS is indicated for the treatment of drug overdose and poisonings. The only requirement is that the drug or chemical be dialyzable (in unbound form) and bound by charcoal and/or ion exchange resins.

MARS is not indicated for the treatment of chronic liver disease conditions or as a bridge to liver transplant. Safety and efficacy has not been demonstrated for those indications in controlled, randomized clinical trials. The effectiveness of the MARS device in patients that are sedated could not be established in clinical studies and therefore cannot be predicted in sedated patients.