Drug Overdose and Poisoning

The MARS (Molecular Adsorbent Recirculating System) therapy works easily with your PRISMAFLEX System to support the removal of harmful drugs and poisons in combination with CRRT

The MARS is indicated for the treatment of drug overdose and poisoning. The only requirement is that the drug or chemical be dialyzable (in unbound form) and bound by charcoal and/or ion exchange resins.

Photo with labels for MARS Monitor, X-MARS Kit, connected to the PRISMAFLEX System.

X-Mars Kit includes the 1) MARS FLUX 2.1 - high flux dialyzer especially suited for removing protein-bound toxins from the patient's blood by means of an HSA dialysate, 2) diaMARS IE250 - this adsorber cartridge is filled with an ion-exchanger resin, especially suited for eliminating anionic molecules, 3) diaMARS AC250 and 4) diaFLUX 1.4

MARS Monitor for PRISMAFLEX with labels for bag holder, albumin dialysate heater, blood leak detector, particle filter holder, holder for diaLFUX filter holder (when not used in conbination with PRISMAFLEX System, air trap holder with level detector, albumin pump.

When a patient comes in from a drug overdose or from a poison that’s killing the liver cells, albumin dialysis using the MARS therapy helps me to stabilize my patient, and gives them the chance to recover. If you have a dialysis service, you can have MARS up and running very easily.

Tarek Hassanein, MD

Established first MARS program in the US, Over 500 patients treated with MARS

How It Works

mars diaflux diamars diagram drug poisoning

MARS is comprised of a blood circuit, an albumin circuit, and a classic CRRT circuit.

MARS therapy removes unbound water-soluble or protein-bound toxins by dialyzing the patient's blood against albumin-enriched dialysate across an albumin-impregnated, high-flux filter (MARSFLUX).
Utilization of the albumin-based MARS circuit in conjunction with the PRISMAFLEX device allows protein-bound molecules to be transferred from the patient's blood to the protein in the dialysate.
The dialysate containing the removed toxins is subsequently purified by passage through two sorbent column (activated charcoal and ion-exchange resin) and a secondary low-flux dialyser before being recirculated.
This purification process allows for a constant supply of regenerated albumin dialysate to the MARSFLUX filter.

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Drug Overdose and Poisoning

How It Works

MARS is comprised of a blood circuit, an albumin circuit, and a classic CRRT circuit.

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